Articles articles

service

Your Position:Home > Articles > Tunable T1 and T2 contrast abilities of manganeseengineered iron oxide nanoparticles through size control

Hot Articles1

Hot Products1

Tunable T1 and T2 contrast abilities of manganeseengineered iron oxide nanoparticles through size control

Tunable T1 and T2 contrast abilities of manganeseengineered iron oxide nanoparticles through size control


Abstract


In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contrast agents with controllable T1 and T2 contrast abilities is of high importance in the field of molecular imaging. In this study, we synthesized uniform manganese-doped iron oxide (MnIO) nanoparticles with controllable size from 5 to 12 nm and comprehensively investigated their MRI contrast abilities. We revealed that the MRI contrast effects of MnIO nanoparticles are highly size-dependent. By controlling the size of MnIO nanoparticles, we can achieve T1-dominated, T2-dominated, and T1–T2 dual-mode MRI contrast agents with much higher contrast enhancement than the corresponding conventional iron oxide nanoparticles.

Recommended instruments for related researches



PQ001 NMR Relaxometry


NMI20 MRI Contrast Agent Analyzer


Mobile:+86-15618809683 | Email: info@niumag.com |Skype: niumagnmr