Articles articles

service

Your Position:Home > Articles > The photoluminescence, drug delivery and imaging properties of multifunctional Eu3þ/Gd3þ dual-doped hydroxyapatite nanorods

Hot Articles1

Hot Products1

The photoluminescence, drug delivery and imaging properties of multifunctional Eu3þ/Gd3þ dual-doped hydroxyapatite nanorods

The photoluminescence, drug delivery and imaging properties of multifunctional
Eu3þ/Gd3þ dual-doped hydroxyapatite nanorods


Abstract


The design and synthesis of multifunctional systems with high biocompatibility are very significant for the future of clinical applications. Herein, we report a microwave-assisted rapid synthesis of multifunctional Eu3þ/Gd3þ dual-doped hydroxyapatite (HAp) nanorods, and the photoluminescence (PL), drug delivery and in vivo imaging of as-prepared Eu3þ/Gd3þ doped HAp nanorods. The photoluminescent and magnetic multifunctions of HAp nanorods are realized by the dual-doping with Eu3þ and Gd3þ. The PL intensity of doped HAp nanorods can be adjusted by varying Eu3þ and Gd3þ concentrations. The magnetization of doped HAp nanorods increases with the concentration of doped Gd3þ. The as-prepared Eu3þ/Gd3þ-doped HAp nanorods exhibit inappreciable toxicity to the cells in vitro. More importantly, the Eu3þ/Gd3þ-doped HAp nanorods show a high drug adsorption capacity and sustained drug release using ibuprofen as a model drug, and the drug release is governed by a diffusion process. Furthermore, the noninvasive visualization of nude mice with subcutaneous injection indicates that the Eu3þ/Gd3þ-doped HAp nanorods with the photoluminescent function are suitable for in vivo imaging. In vitro and in vivo imaging tests indicate that Eu3þ/Gd3þ-doped HAp nanorods have a potential in applications such as a multiple-model imaging agent for magnetic resonance (MR) imaging, photoluminescence imaging and computed tomography (CT) imaging. The Eu3þ/Gd3þ dual-doped HAp nanorods are promising for applications in the biomedical fields such as multifunctional drug delivery systems with imaging guidance.

Recommended instruments for related researches



PQ001 NMR Relaxometry


NMI20 MRI Contrast Agent Analyzer


Mobile:+86-15618809683 | Email: info@niumag.com |Skype: niumagnmr