Articles articles

service

Your Position:Home > Articles > Rational strategy of magnetic relaxation switches for glycoprotein sensing

Hot Articles1

Hot Products1

Rational strategy of magnetic relaxation switches for glycoprotein sensing

Rational strategy of magnetic relaxation switches for glycoprotein sensing


Abstract


A rational strategy of magnetic relaxation switches was proposed here to detect a1-acid glycoprotein (AGP), an acute phase a-globulin plasma glycoprotein. The assay was based on the relaxation time change between the aggregation of magnetic nanoparticles with concanavalin A and the redispersion with AGP, which can avoid the prozone effect and improve the detection accuracy. The assay was an easy and efficient method with two mixing steps and one measurement step, showing a detection limit of 0.66 nM in 00.3 mg mL1 AGP, which was far lower than its normal level in human plasma.In this study, we present the detection of glycoproteins with magnetic relaxation switches (MRS).12 MRS is a novel detection method based on the transverse relaxation time (T2) change of water protons between dispersion and aggregation of functional magnetic nanoparticles by the binding with analyte, and it has been used to detect a variety of targets ranging from small molecules such as DNA, peptide, metal ion to macromolecules such as protein, virus, bacteria and cell.13 It is suitable for the detection in complex media because the assay is based on the magnetic properties.

Recommended instruments for related researches



PQ001 NMR Relaxometry


NMI20 MRI Contrast Agent Analyzer


Mobile:+86-15618809683 | Email: info@niumag.com |Skype: niumagnmr